RT3-AT Reciprocating Cylinder Dissolution System
Manufactured for precise dissolution tests with automated samples and filtering mechanisms is the RT3-AT Reciprocating Cylinder Dissolution System. This unit has an integrated coaxial bracket that enables fast mount replacements for holders alongside automatic vessel lids that protect against evaporation over time. The design incorporates a single-piece water bath which provides uniform heating properties and full drainage. The equipment operates with a high-precision sampling pump as well as an advanced Teflon pipeline system which prevents sample adsorption and maintains accurate results. Users can adjust the parameters for reciprocating stroke position alongside rate immersion duration and drainage duration according to FDA 21 CFR Part 11 standards.
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- Short Piping Lengths
- Efficient Pipeline Lubrication
- Precision Sampling
- Sufficient Secondary Filtration
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description
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The RT3-AT technology provides realistic in vivo mechanical environments that suit the examination of functional gummies and enteric tablets combined with soft capsules as well as orally disintegrating tablets. The system enables users to adjust pH settings to simulate stomach environment conditions.
This instrument achieves high-precision dissolution testing for automatic sampling it provides multi-stage filtration along with a user-friendly touchscreen interface that ensures data integrity.
Features
Co-axial Mounting Bracket
The coaxial split design makes it quickly to replace the reciprocating cylinder with other reciprocating holder.
Automatic Dissolution Vessel Cover
The cover of dissolution vessel can automatically open and close, effectively reducing the evaporation loss of the dissolution medium.
One-piece water bath
One-piece rounded corners water bath with no dead spots and can be thoroughly drained.
Complete filtration program
Equipped with pre-pump filtration device, it can be installed with various sizes of cylindrical filter elements. It is also possible to install a disk-shaped filter head at the front of the injection needle of the automatic sampling workstation to realize on-line filtration.
Precise sampling
High-precision sampling pump which can effectively provide accurate and precise sampling.
Pipeline System
Teflon pipeline system with high chemical stability and high anti-adsorption was used to avoid corrosion of sampling pipeline or sample adsorption.
Flexible setting of experimental parameters
The reciprocating rate, reciprocating stroke, immersion time and drain time can be set.
Wide range of dissolution vessel sizes
Available with 300mL or optional 1000mL dissolving cup for testing
User-computer Interface
8.4-inch touch screen, preinstalled with the Raytor dissolution operating system, meeting the data integrity requirements.
Application
Compared to paddle and basket methods, the reciprocating cylinder method is able to provide more enhanced hydrodynamic forces by adjusting the reciprocating stroke and reciprocating frequency. It better simulates the mechanical stresses of chewing or in the body. It also supports changing the pH of the dissolution medium to simulate human gastrointestinal conditions.
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Functional Gummies
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Enteric tablets
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Soft capsule
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orally disintegrating tablets
Specifications
Product Brochure
Reciprocating Cylinder Dissolution System
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Length ×Width× Height(Fully Raised): 80cm × 63cm ×100 cm |
Dissolution Vessel Row Number: 7 tubes×6 Rows (300mL Stand Vessel) |
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Dissolution System Level: ≤ 0.3° |
Shaft Verticality: ≤ 90°± 0.5° |
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Temperature Control Range: Room Temperature ~ 50℃ |
Temp. Resolution: 0.1 ℃ |
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Temp. Accuracy: ≤ ± 0.2℃ |
Vessels Temp. Difference: ≤ ± 0.5℃ |
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Adjustable Range of Reciprocating Stroke: 2 ~ 10 cm |
Error of Reciprocating Stroke: ≤ ± 0.1 cm |
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Adjustable Range of Reciprocating Rate: 4 ~ 60 DPM |
Error of Reciprocating Rate: ≤ ±5% |
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Maximum Running Time: 600 (Hours) |
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Automatic Sampling Workstation
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Maximum Settable Sampling Number: 30 Times |
Maximum Sampling Volume: 1~10ml |
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Sampling Precision: ≤±1% |
Sample Collector: Suitable for 10ml Test Tube or HPLC Vial |
Operating System
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Meeting FDA21 CFR Part 11 |
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